![]() ![]() ![]() ![]() The primary end points were efficacy of the vaccine against laboratory-confirmed Covid-19 and safety.Ī total of 43,548 participants underwent randomization, of whom 43,448 received injections: 21,720 with BNT162b2 and 21,728 with placebo. BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine that encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. In an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years of age or older in a 1:1 ratio to receive two doses, 21 days apart, of either placebo or the BNT162b2 vaccine candidate (30 μg per dose). Safe and effective vaccines are needed urgently. ![]() Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. 1 From Fundacion INFANT (F.P.P.) and iTrials-Hospital Militar Central (G.P.M.), Buenos Aires State University of New York, Upstate Medical University, Syracuse (S.J.T.), and Vaccine Research and Development, Pfizer, Pearl River (J.A., A.G., K.A.S., K.K., W.V.K., D.C., P.R.D., K.U.J., W.C.G.) - both in New York Vaccine Research and Development, Pfizer, Hurley, United Kingdom (N.K., S.L., R.B.) Vaccine Research and Development (J.L.P., P.L.) and Worldwide Safety, Safety Surveillance and Risk Management (S.M.), Pfizer, Collegeville, PA Associação Obras Sociais Irmã Dulce and Oswaldo Cruz Foundation, Bahia (E.D.M.), and Centro Paulista de Investigação Clinica, São Paulo (C.Z.) - both in Brazil Global Product Development, Pfizer, Peapack, NJ (S.R.) Cincinnati Children's Hospital, Cincinnati (R.W.F.) Johns Hopkins Bloomberg School of Public Health, Baltimore (L.L.H.) BioNTech, Mainz (ÖT., U.Ş.), and Medizentrum Essen Borbeck, Essen (A.S.) - both in Germany Tiervlei Trial Centre, Karl Bremer Hospital, Cape Town, South Africa (H.N.) Hacettepe University, Ankara, Turkey (S.Ü.) and Worldwide Safety, Safety Surveillance and Risk Management, Pfizer, Groton, CT (D.B.T.).Judith Aberg, Marylyn Addo, Sıla Akhan, Timothy Albertson, Mohamed Al-Ibrahim, Sedat Altın, Corey Anderson, Charles Andrews, Samir Arora, Ismail Balik, Elizabeth Barnett, George Bauer, Sybille Baumann-Noss, Mezgebe Berhe, Paul Bradley, Donald Brandon, Daniel Brune, Abram Burgher, Bain Butcher, David Butuk, Kevin Cannon, Jose Cardona, Rachael Cavelli, Fadi Chalhoub, Shane Christensen, Tom Christensen, Laurence Chu, Steven Cox, Gretchen Crook, Matthew Davis, Rajesh Davit, Douglas Denham, Michael Dever, Curtis Donskey, Matthew Doust, Michael Dunn, John Earl, Frank Eder, Andreas Eich, David Ensz, Brandon Essink, Robert Falcone, Ann Falsey, Cecil Farrington, Robert Finberg, Daniel Finn, David Fitz-Patrick, Stephen Fortmann, Leon Fouche, Veronica Fragoso, Robert Frenck, David Fried, Gregory Fuller, Suzanne Fussell, Julia Garcia-Diaz, Andrew Gentry, Richard Glover, Carla Greenbaum, Stephen Grubb, Laura Hammitt, Charles Harper, Wayne Harper, Aaron Hartman, Robert Heller, Ernest Hendrix, Darrell Herrington, Timothy Jennings, Oğuz Karabay, Steven Kaster, Steven Katzman, Jeffrey Kingsley, Nicola Klein, Tracy Klein, Mark Koch, Iftahar Köksal, Michael Koren, Mark Kutner, Marcus Lee, Mark Leibowitz, Michael Levin, Romina Libster, Michael Lillestol, Christopher Lucasti, Matthias Luttermann, Mary Beth Earl Manning, Martin Martin, Paul Matherne, James McMurray, Ali Mert, Randle Middleton, Essack Mitha, Emily Morawski, Edson Moreira, Mark Mulligan, Alexander Murray, Murtaza Mussaji, Dany Musungaie, Haylene Nell, Larry Odekirk, Onyema Ogbuagu, Kristopher Paolino, Suchet Patel, James Peterson, Paul Pickrell, Fernando Polack, Donald Poretz, George Raad, William Randall, Bruce Rankin, Steven Reynolds, Robert Riesenberg, Hector Rodriguez, Jeffrey Rosen, John Rubino, Richard Rupp, Salma Saiger, Robert Salata, Jamshid Saleh, Axel Schaefer, Martin Schear, Armin Schultz, Howard Schwartz, Nathan Segall, William Seger, Shelly Senders, Stephan Sharp, Sylvia Shoffner, Serap Simsek Yavuz, Teresa Sligh, William Smith, Helen Stacey, Michael Stephens, Harry Studdard, Fehmi Tabak, Kawsar Talaat, Stephen Thomas, William Towner, Van Tran, Serhat Ünal, Lisa Usdan, John Vanchiere, Susann Varano, Edward Tyler L Wadsworth, Walsh Walsh, Emmanuel Walter, Diego Wappner, Rick Whiles, Hayes Williams, Jonathan Wilson, Peter Winkle, Patricia Winokur, Thomas Wolf, Joseph Yozviak, Cristiano Zerbini ![]()
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